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Evaluating African-Derived mtDNA Haplotype Diversity Via Independent Sample Collections

NCJ Number
231839
Journal
Canadian Society of Forensic Science Journal Volume: 43 Issue: 2 Dated: June 2010 Pages: 65-74
Author(s)
Jamie L. Wilson; Bert Ely; Bruce A. Jackson
Date Published
June 2010
Length
10 pages
Annotation

This study compared independent samples of African ethnic groups living in modern-day Cameroon to compare replicate samples of the HVS-1 mtDNA sequences from the Bamileke and Fulbe ethnic groups from Cameroon.

Abstract

Since the sample sizes for forensic cases, as well as studies of African ethnic groups, are usually low, and independent samples are rare. It has been difficult to determine whether small samples contain an accurate representation of a sampled population. In this study, two independent samples of the Bamileke had similar values with regard to standard and molecular diversity indices and selective neutrality. The two Fulbe samples were also similar, but they differed with respect to selective neutrality values. In both ethnic groups, shared haplotypes were present at low frequencies. However, the Fulbe had fewer exclusive matches with outside ethnic groups compared to the Bamileke. Nevertheless, in both ethnic groups, within-group matches were more common than matches to any other Cameroonian potential for being ethnic and/or region specific. To assess this potential, sample sizes will have to be orders of magnitude larger in order to observe significant numbers of those relatively rare haplotypes. However, as database size is increased, haplotype sharing will correspondingly increase; and many haplotypes that are common in a single ethnic group will also be found in multiple ethnic groups. Tables and references (Published Abstract)