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NCJ Number: NCJ 241439   Add to Shopping cart   Find in a Library
Title: Designer Amphetamines in Forensic Toxicology Casework
Author(s): Sarah Kerrigan Ph.D.
Date Published: 07/2012
Page Count: 90
Sponsoring Agency: National Institute of Justice
US Department of Justice
Office of Justice Programs
United States of America
Grant Number: 2008-DN-BX-K126
Sale Source: NCJRS Photocopy Services
Box 6000
Rockville, MD 20849-6000
United States of America
Document: PDF 
Type: Report (Grant Sponsored)
Language: English
Country: United States of America
Annotation: This final report presents the results of a study to evaluate limitations in existing methodology for detecting designer amphetamines in toxicology screenings and to develop new procedures for detecting these drugs.
Abstract: Existing methods used in forensic toxicology laboratories are currently unable to readily detect the newer forms of designer amphetamines being seized by law enforcement. In this study, 11 psychedelic amphetamines (2C, 2C-T, and DO series) were used to determine the cross-reactivity of 9 commercial enzyme-linked immunosorbent assays (ELISAs). The analysis found that the 9 ELISAs exhibited some cross-reactivity towards one of the drugs, 4-methylthioamphetamine (4-MTA), while cross-reactivity towards the remaining 10 drugs was extremely low, less than 0.4 percent. This finding suggests the detection of any of these 11 drugs would be extremely unlikely in standard forensic toxicology screenings. The study also developed and tested a new procedure for detecting the new designer drugs. Gas chromatography/mass spectrometry (GC/MS) and solid phase extraction (SPE) were used in a procedure that involved the simultaneous detection of the 11 psychedelic amphetamines. The study also tested the ability of liquid chromatography-tandem mass spectrometry (LC/MS/MS) to be used for the simultaneous detection of these drugs. The findings from the study indicate that using both GC/MS and LC/MS/MS improves the ability to detect forensically significant concentrations of these types of drugs in blood and urine samples. Study limitations are discussed. Tables, figures, references
Main Term(s): Blood/body fluid analysis
Index Term(s): Amphetamines ; Drug detection ; Forensics/Forensic Sciences ; Designer drugs ; NIJ final report ; NIJ grant-related documents ; Drug Use Indicators
   
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https://www.ncjrs.gov/App/Publications/abstract.aspx?ID=263529

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