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NCJRS Abstract

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NCJ Number: 252919 Find in a Library
Title: Automated Derivatization and Identification of Controlled Substances via Total Vaporization Solid Phase Microextraction (TV-SPME) and Gas Chromatography/Mass Spectrometry (GC/MS)
Author(s): John V. Goodpaster
Date Published: May 2019
Page Count: 14
Sponsoring Agency: National Institute of Justice (NIJ)
Washington, DC 20531
Trustees of Indiana University

US Dept of Justice NIJ Pub
Washington, DC 20531
Grant Number: 2015-DN-BX-K058
Sale Source: US Dept of Justice NIJ Pub
810 Seventh Street, NW
Washington, DC 20531
United States of America
Document: PDF
Type: Program/Project Description; Report (Grant Sponsored); Report (Study/Research); Report (Summary); Research (Applied/Empirical)
Format: Document; Document (Online)
Language: English
Country: United States of America
Annotation: This is the Final Summary Overview of a project with the objective of improving the analysis of thermally unstable drugs by gas chromatography/mass spectrometry through a combination of derivatization and a novel total vaporization technique (Total Vaporization - Solid Phase Microextraction).
Abstract: The hypothesis tested was that Total Vaporization - Solid Phase Microextraction (TV-SPME) will offer greater sensitivity than traditional liquid injection for controlled substances. In addition, TV-SPME was easily adapted to include either a pre-extraction or a post-extraction on-fiber derivatization step for thermally labile species. Project results were promising for all drug classes that were analyzed successfully by on-fiber derivatization as solutions. This discovery greatly improves the utility of the technique, since controlled substances are most often encountered in their solid forms in forensic science laboratories. The application of this technique to beverage samples and solid drug powders is of most interest, since these applications involve a significant decrease in sample preparation. Although not ideal for all analytes, TV-SPME with on-fiber derivatization could be a powerful techniqe for amine and hydroxylamine controlled substances, as well as GHB. The technique could increase analyst efficiency by reducing sample preparation time for these types of analytes. Thus, the main results of this project are a set of optimized derivatization methods that can be used in liquid injection or TV-SPfsME. This approach offers the possibility of automated sampling and derivatization for a wide variety of thermally labile compounds and the analysis of compounds that require no derivatization. Project design and methods are described. 4 figures and 1 table
Main Term(s): Forensic sciences
Index Term(s): Automation; Drug analysis; Drug detection; National Institute of Justice (NIJ); NIJ final report
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