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NCJ Number: NCJ 240977     Find in a Library
Title: Developing a SNP Panel for Forensic Identification of Individuals
Journal: Forensic Science International  Volume:164  Issue:1  Dated:2006  Pages:20 to 32
Author(s): Kenneth K. Kidd ; Andrew J. Pakstis ; William C. Speed ; Elena L. Grigorenko ; Sylvester L.B. Kajuna ; Nganyirwa J. Karoma ; Selemani Kungulilo ; Jong-Jin Kim ; Ru-Band Lu ; Adekunle Odunsi ; Friday Okonofua ; Josef Parnas ; Leslie O. Schulz ; Olga V. Zhukova ; Judith R. Kidd
Date Published: 2006
Page Count: 13
Sponsoring Agency: National Institute of Justice
US Department of Justice
Office of Justice Programs
United States of America
Grant Number: 2004-DN-BX-K025
Type: Report (Study/Research)
Language: English
Country: United States of America
Annotation: This paper describes an efficient strategy for identifying and characterizing single nucleotide polymorphisms (SNPs) that show little allele frequency variation among populations while remaining highly informative; and it reports on testing this strategy on a broad representation of world populations.
Abstract: The narrow range in the distribution of the average match probability across populations validates the low Fst strategy for identifying SNPs for use in forensic human identification. Although Fst depends on the specific set of populations studied, it is clear that a global set of DNA samples can be used to screen for markers with globally uniform Fst values. Selecting markers based on low Fst has the additional benefit of minimizing any differential effect balancing selection in a particular population or geographical region may have. With low Fst SNPs, whatever balancing selection may exist at any SNP must exist in all populations. The strategy used consists of four steps: first likely candidate polymorphisms are identified. Second these are screened on a few populations. Third the best of these markers are tested on many populations. Fourth the “best of the best” markers are retained. The “best of the best” are those with the highest average heterozygosity and lowest variation among populations, which are the most likely to be useful for individual forensic identification. Fst is used as a standardized measure of the variance in allele frequencies among populations. Regarding methodology, this report addresses screening criteria, marker typing, and analytic methods. 5 tables, 6 figures, and 23 references
Main Term(s): Forensics/Forensic Sciences
Index Term(s): Victim identification ; Suspect identification ; Investigative techniques ; DNA fingerprinting ; NIJ grant-related documents
   
  To cite this abstract, use the following link:
https://www.ncjrs.gov/App/Publications/abstract.aspx?ID=263065

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