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NCJ Number: NCJ 241061     Find in a Library
Title: SAMP14, a Novel, Acrosomal Membrane-associated,Glycosylphosphatidylinositol-Anchored Member of the Ly-6/Urokinase-Type Plasminogen Activator Receptor Superfamily With a Role in Sperm-Egg Interaction
Author(s): Jagathpala Shetty ; Michael J. Wolkowicz ; Laura C. Diglio ; Kenneth L. Klotz ; Friederike L. Jayes ; Alan B. Diekman ; V. Anne Westbrook ; Erin M. Farris ; Zhonglin Hao ; Scott A. Coonrod ; Charles J. Flickinger ; John C. Herr
  Journal: Journal of Biological Chemistry  Volume:278  Issue:33  Dated:August 2003  Pages:30506 to 30515
Date Published: 08/2003
Page Count: 10
  Annotation: This paper reports a new member of the Ly-6/urokinase-type plasminogen activator receptor (uPAR) superfamily of receptors, SAMP14, which is retained on the inner acrosomal membrane of the human spermatozoan following the acrosome reaction; it may have a role in fertilization.
Abstract: The hamster egg penetration assay performed in the study showed that antibody against SAMP14 significantly inhibited both the binding and fusion of sperm with zona free hamster eggs, which suggests that SAMP14 may have role in one or more events leading to fertilization. It is well known that the equatorial region of the sperm contacts the vitelline membrane prior to sperm internalization. Further, following the acrosome reaction, the inner acrosomal membrane is known to come directly in contact with the egg, leading to the later events of egg penetration. Considering that the concentrations of SAMP14 were highest in the posterior acrosome close to the equatorial region and that it is retained and localized in the inner acrosomal membrane, it is not surprising that the antibody to SAMP14 inhibited both sperm-egg binding and fusion. Recently, another acrosomal membrane protein SAMP32 also localized to the inner acrosomal membrane of the principal piece and equatorial segments. Further, anti-SAMP32 blocked the penetration of zona free hamster eggs by human sperm. The authors conclude that SAMP14 merits further evaluation as a GPI-linked receptor that is retained on the inner acrosomal membrane after acrosomal exocytosis. 8 figures and 44 references
Main Term(s): Forensics/Forensic Sciences
Index Term(s): Biological influences ; Adolescent pregnancy ; NIJ grant-related documents
Sponsoring Agency: National Institute of Justice (NIJ)
US Department of Justice
Office of Justice Programs
United States of America

US Dept of Health and Human Service
National Institutes of Health
Office of Behavioral and Social Sciences
United States of America

Fogarty International Ctr
United States of America
Grant Number: 2000-IJ-CX-K013;D43 TW/HD 00654;HD U5429099
Type: Report (Study/Research)
Country: United States of America
Language: English
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