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NCJ Number: NCJ 241066     Find in a Library
Title: Sub-Populations Within the Major European and African Derived Haplogroups R1b3 and E3a are Differentiated by Previously Phylogenetically Undefined Y-SNPs
Author(s): Lynn M. Sims ; Dennis Garvey ; Jack Ballantyne
  Journal: Human Mutation  Volume:97  Issue:1  Dated:2007  Pages:1 to 7
Date Published: 2007
Page Count: 7
  Annotation: This study used a sample of 118 African-Americans and 125 European-Americans in evaluating 12 previously phylogenetically undefined Y-SNPs for their ability to further differentiate individuals who belong to the major African (E3a)-derived and European (R1b3, I)-derived haplogroups.
Abstract: Major Y-SNP haplogroups were determined with 56 well-defined Y-SNPs, using a hierarchical typing strategy with the described pyrosequencing technology for genotyping. Ten of these markers define seven new subclades within haplogroups E and R. Using the Y Chromosome Consortium nomenclature, these new subclades are equivalent to E3a7a, E3a8, E3a8a, E3a8a1, R1b3h, R1b3i, and R1b3i1. During the study, the authors evaluated M222, a sub-Rib3 marker rarely used, and they found that this sub-haplogroup defines the Y-STR Irish Modal Haplotype (IMH). These new bi-allelic markers can be applied in human evolutionary studies and forensic genetics. The descriptions of materials and methods address candidate marker selection; genomic DNA isolation, PCR, and genotyping; and phylogenetic and statistical analysis. 1 table, 1 figure, and 25 references
Main Term(s): Forensics/Forensic Sciences
Index Term(s): Victim identification ; Suspect identification ; Investigative techniques ; DNA fingerprinting ; Parentage determination ; NIJ grant-related documents
Sponsoring Agency: National Institute of Justice (NIJ)
US Department of Justice
Office of Justice Programs
United States of America
Grant Number: 98-IJ-CX-K003; 2005-MU-MU-K044
Type: Report (Study/Research)
Country: United States of America
Language: English
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