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NCJ Number: NCJ 241143     Find in a Library
Title: Impact of Additional Y-STR Loci on Resolving Common Haplotypes and Closely Related Individuals
Author(s): A.E. Decker ; M.C. Kline ; P.M. Vallone ; J.M. Butler
  Journal: Forensic Science International: Genetics  Volume:1  Dated:2007  Pages:215 to 217
Date Published: 2007
Page Count: 3
  Annotation: In examining the impact of Y-STR markers beyond the 17 loci now available in commercial kits, new Y-STR loci are being examined on a common set of samples representative of the major U.S. population groups.
Abstract: Two commercial Y-chromosome STR kits are widely available for amplifying 12 or 17 Y-STR loci. Using these commercial kits as a starting point, this study screened additional loci in order to determine their ability to resolve U.S. population samples. After testing, 20 of these loci were assessed in conjunction with the Yfiler loci regarding their ability to resolve the most common haplotype observed in 656 U.S. population samples. Typing of these samples revealed a common haplotype that was observed 26 times with only the minimal haplotype that was observed 26 times with only the minimal haplotype loci; therefore, approximately 4 percent of the samples were unresolved using these nine loci. Adding DYS438 and DYS439 loci breaks these samples into three groups. The additional locus DYS437 on the Powerplex Y kit further resolves the samples into seven groups. The Y filer kit adds five more loci, separating all but three samples with the most common type. Adding either DYS522 or DYS576 to the Yfiler loci resolves all 25 samples with the most common type. In this population set, 7 of the 20 additional Y-STRs have the same ability to resolve sample haplotypes as all 20 loci, which demonstrates promise for future multiplexing. These loci include DYS449, DYS505, DYS522, DYS532, DYS534, DYS570, and DYS576. Future studies will evaluate other YSTRs beyond these 37 loci, which may also be useful in Y-STR testing communities. 1 table and 7 references
Main Term(s): Forensics/Forensic Sciences
Index Term(s): Victim identification ; Suspect identification ; Investigative techniques ; DNA fingerprinting ; Parentage determination ; NIJ grant-related documents ; United States of America
Sponsoring Agency: National Institute of Justice (NIJ)
US Department of Justice
Office of Justice Programs
United States of America
Grant Number: 2003-IJ-R-029
Type: Report (Study/Research)
Country: United States of America
Language: English
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