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NCJ Number: NCJ 241199     Find in a Library
Title: SLLP1, A Unique, Intra-Acrosomal, Non-Bacteriolytic, C Lysozyme-like Protein of Human Spermatozoa
Author(s): Arabinda Mandal ; Kenneth L. Klotz ; Jagathpala Shetty ; Friederike L. Jayes ; Michael J. Wolkowicz ; Laura C. Bolling ; Scott A. Coonrod ; Michael B. Black ; Alan B. Diekman ; Timothy A. J. Haystead ; Charles J. Flickinger ; John C. Herr
  Journal: Biology of Reproduction  Volume:68  Issue:5  Dated:2003  Pages:1525 to 1537
Date Published: 2003
Page Count: 13
  Annotation: This study investigated the presence of a unique c lysozyme-like protein in human spermatozoa.
Abstract: During research that included mining of a human two-dimensional gel sperm proteome, scientists discovered the presence of several novel proteins including a unique c lysozyme-like protein identified as SLLP1. C lysozymes (chicken-type lysozymes) are N-acetylglucosamine-binding proteins that have not yet been identified as being present in human sperm. These proteins are important as they could play a possible role in sperm/egg adhesion during fertilization. This article describes the extraction and separation of sperm proteins from samples of human semen that tested negative by serology for HIV. The proteins were microsequenced and cloned, and a number of different analyses were conducted on the separated proteins. The study found that when antisera to SPPL1 were introduced, it blocked binding in the hamster egg penetration assay. This finding suggests that SPPL1 may have a role to play in binding the sperm to the egg during fertilization however; the specifics of this role will need to be examined in additional research. Tables, figures, and references
Main Term(s): Forensics/Forensic Sciences
Index Term(s): Evidence identification and analysis ; Forensic pathology ; Forensic engineering ; NIJ grant-related documents
Sponsoring Agency: Andrew W Mellon Foundation
United States of America

National Institute of Justice (NIJ)
US Department of Justice
Office of Justice Programs
United States of America

Fogarty International Ctr
United States of America
Grant Number: 2000-IJ-CX-K013;D43 TW/HD 00654;NIH HD U54 29099;P30 28934
Type: Research (Applied/Empirical)
Country: United States of America
Language: English
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