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The document referenced below is part of the NCJRS Library collection.
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NCJ Number: NCJ 241217     Find in a Library
Title: Trace Detection of Meglumine and Diatrizoate from Bacillus Spore Samples Using Liquid Chromatography/Mass Spectrometry
  Document URL: HTML 
Author(s): Catherine Swider, B.S. ; Kelly Maguire, M.S. ; Michael Rickenbach, Ph.D. ; Madeline Montgomery, B.S. ; Matthew J. Ducote, Ph.D. ; Craig A. Marhefka, Ph.D.
  Journal: Journal of Forensic Sciences  Volume:57  Issue:4  Dated:July 2012  Pages:923 to 931
Date Published: 07/2012
Page Count: 9
  Annotation: This article discusses the purification of B. anthracis spores.
Abstract: Following the September 11, 2001 terrorist attacks, letters containing Bacillus anthracis were distributed through the United States postal system killing five people. A complex forensic investigation commenced to identify the perpetrator of these mailings. A novel liquid chromatography/mass spectrometry protocol for the qualitative detection of trace levels of meglumine and diatrizoate in dried spore preparations of B. anthracis was developed. Meglumine and diatrizoate are components of radiographic imaging products that have been used to purify bacterial spores. Two separate chromatographic assays using multiple mass spectrometric analyses were developed for the detection of meglumine and diatrizoate. The assays achieved limits of detection for meglumine and diatrizoate of 1.00 and 10.0 ng/mL, respectively. Bacillus cereus T strain spores were effectively used as a surrogate for B. anthracis spores during method development and validation. This protocol was successfully applied to limited evidentiary B. anthracis spore material, providing probative information to the investigators. Abstract published by arrangement with John Wiley & Sons.
Main Term(s): Forensics/Forensic Sciences
Index Term(s): Chromatography ; Trace evidence ; Evidence identification and analysis ; Mass spectroscopy ; Chemical irritants ; Domestic terrorism ; Chemical Weapons
Type: Report (Technical)
Country: United States of America
Language: English
   
  To cite this abstract, use the following link:
https://www.ncjrs.gov/App/Publications/abstract.aspx?ID=263307

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