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NCJ Number: NCJ 241235     Find in a Library
Title: Evaluation of 96 SNPs in 14 Populations for Worldwide Individual Identification
  Document URL: HTML 
Author(s): Zhaoshu Zeng, Ph.D. ; Li Wang, M.D. ; Qingchuan Feng, Ph.D. ; Lirong Zhang, M.D., Ph.D. ; Li Lee, M.D. ; Lei Wang, M.D. ; Yangli Yue, M.D. ; Yu Fang, M.D., Ph.D. ; Weihong Yang, M.D. ; Hanmei Qiu, M.D. ; Ziming Dong, M.D., Ph.D.
  Journal: Journal of Forensic Sciences  Volume:57  Issue:4  Dated:July 2012  Pages:1031 to 1035
Date Published: 07/2012
Page Count: 5
  Annotation: The researchers of this study describe a new computational strategy for developing IDSNPs based on HapMap.
Abstract: Great advances have been made recently in searching for individual identification single-nucleotide polymorphisms (IISNPs or IDSNPs). Such SNPs as suggested by SNPforID scientists and by Pakstis et al., are promising, although they were selected from older or smaller databases rather than the most recent database. Here, researchers describe a new computational strategy for developing IDSNPs based on HapMap. Researchers searched through HapMap r27 for SNPs having minor allele frequencies greater than 0.30 in all its 11 populations and found more than 1,881 qualified SNPs. Researchers examined 96 of them with 183 DNA samples from 3 Chinese populations using Illumina arrays. The average allele frequency for these 96 SNPs among the 3 populations was 0.495/0.505, the average number of identical SNP genotypes shared by two individuals among the 14 populations (three Chinese and 11 HapMap) was 37.9, and the random matching probability for two unrelated Hans to match in all 96 genotypes was 9.793 × 10-39. Thus, most of these 96 SNPs are universally applicable. Abstract published by arrangement with John Wiley & Sons.
Main Term(s): Forensics/Forensic Sciences
Index Term(s): Scientific techniques ; DNA fingerprinting ; Gender determination ; Chinese
Type: Research (Applied/Empirical)
Country: United States of America
Language: English
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