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NCJRS Abstract

The document referenced below is part of the NCJRS Library collection. To conduct further searches of the collection, visit the NCJRS Abstracts Database. See the Obtain Documents page for direction on how to access resources online, via mail, through interlibrary loans, or in a local library.

 
  NCJ Number: NCJ 242039     Find in a Library
  Title: Comparative Analysis of the Chemical Profiles of 3,4-Methylenedioxymethamphetamine Based on Comprehensive Two-Dimensional Gas Chromatography–Time-of-Flight Mass Spectrometry (GC × GC-TOFMS)
  Document URL: HTML 
  Author(s): Marion Schaffer, M.Sc. ; Thomas Groger, M.Sc. ; Michael Putz, Dipl.-Chem ; Susanne Dieckmann, Dipl.-Chem ; Ralf Zimmermann, Ph.D.
  Journal: Journal of Forensic Sciences  Volume:57  Issue:5  Dated:September 2012  Pages:1181 to 1189
  Date Published: 09/2012
  Page Count: 9
  Annotation: The chemical profiling of illicit drugs is an important analytical tool to support the work of investigating and law enforcement authorities.
  Abstract: The chemical profiling of illicit drugs is an important analytical tool to support the work of investigating and law enforcement authorities. In this work, comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry (GC × GC-TOFMS) combined with nontargeted, pixel-based data analysis was adapted for the chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA). The validity and benefit of this approach was evaluated by analyzing a well-investigated set of MDMA samples. Samples were prepared according to a harmonized extraction protocol to ensure the comparability of the chemical signatures. The nontargeted approach comprises preprocessing followed by analysis of variances as a fast filter algorithm for selection of a variable subset followed by partial least squares discriminant analysis for reduction to promising marker compounds for discrimination of the samples according to their chemical profile. Forty-seven potential marker compounds were determined, covering most of the target impurities known from the harmonized one-dimensional profiling as well as other compounds not previously elucidated. Abstract published by arrangement with John Wiley & Sons.
  Main Term(s): Forensics/Forensic Sciences
  Index Term(s): Chromatography ; Illicit chemicals ; Drug analysis ; Mass spectroscopy ; Methamphetamine
  Type: Report (Technical)
  Country: United States of America
  Language: English
   
  To cite this abstract, use the following link:
https://www.ncjrs.gov/App/Publications/abstract.aspx?ID=264201

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