In defining runaway youth, two categories are distinguished: those who leave a family situation with the potential for reconciliation and homeless youth with no chance for family reunification and no alternative home. A literature review is used to profile runaways. A high percentage are victims of familial neglect and sexual abuse. Types of sexual exploitation are outlined (juvenile prostitution, juvenile and child pornography, interfamily abuse, and child sexual exploitation and molestation). Categorical similarities and differences among these types of sexual exploitation are noted. The study then describes Federal, State, and local responses to runaways as well as approaches and thinking about the delivery of services to runaway and homeless youth involved in prostitution. Case studies are provided for juvenile prostitution programs in Seattle, San Francisco, Minneapolis, and Louisville. The study concludes with a discussion of the law enforcement response to teenage prostitution. 140 references.