NCJ Number
121309
Journal
Journal of Forensic Sciences Volume: 34 Issue: 4 Dated: (July 1989) Pages: 928-961
Date Published
1989
Length
34 pages
Annotation
The seizure in 1986 of a large-scale clandestine laboratory producing both the N-ethyl and the N,N-dimethyl analogs of 3,4-methylenedioxyphenylisopropylamine (3,4-methylenedioxyamphetamine (MDA) and the recent identification of N-hydroxy MDA hydrochloride (HCL) indicate an interest by illegal laboratory operators in the synthesis of noncontrolled MDA analogs.
Abstract
Currently, identification of these new analogs may be hampered due to lack of available standards or reference data or both. This potential problem prompted the synthesis of the following N-substituted MDA analogs: N-methyl, N-ethyl, N-propyl, N-isopropyl, N-hydroxy, and N,N-dimethyl MDA. Each compound was prepared by reductive amination of 3,4-methylenedioxyphenyl-2-propanone (MDP-2-P) using the appropriate amine hydrochloride and sodium cyanoborohydride. In addition, the acetyl derivatives of MDA, N-hydroxy MDA, and MDP-2-P oxime are reported. Spectral and chromatographic data are presented for each of the compounds synthesized. (Author abstract)