An introduction notes that the main focus of in-house counsel with a corporate criminal practice must be on the prevention of criminal activity through the development and administration of a rigorous corporate compliance effort. Where compliance efforts are unsuccessful and the alleged criminal activity becomes the focus of a law enforcement investigation, corporate counsel must try to manage the activities with the goal of avoiding indictment or circumscribing the indictment and increasing the likelihood of a favorable disposition. Both compliance efforts and responses to investigations and indictments require cooperation between a corporation and its employees or agents. However, preventive and defensive mechanisms may produce a gap between corporate and individual interests. Sample letter notifying employees of a criminal investigation is included.