The spread of AIDS is associated with multiple sexual contacts, homosexuality, and intravenous drug use. It has been argued that prostitution may serve as a bridge between high-risk subgroups of the population and society at large. Published evidence on the possible link between prostitution and AIDS consists mainly of two types. First, serological data have been obtained from people known to be prostitutes. Second, an increasing body of literature involves social and behavioral studies based on interview surveys of sellers and buyers of sexual services. The use of both licit and illicit drugs is often linked with sexual behavior. In many societies, for example, alcohol is traditionally associated with dating, courtship, and making sexual contacts. Studies of alcohol, drugs, and prostitution do not definitively conclude that prostitution leads people into drug use or that female drug users turn to prostitution to finance their habits. Evidence, however, does support the conclusion that heavy drinking and the use of illicit drugs are common among prostitutes. Studies of HIV infection among prostitutes reveal wide geographic variations, and most of these studies are of female versus male prostitutes. Further research is recommended to investigate and monitor AIDS risks among both males and females who buy and sell sexual services. Peer education and outreach services to foster condom use and increase the awareness of AIDS risks are also suggested. 17 references