Several drug testing programs have been subjected to scrutiny under various constitutional amendments, and a recent circuit court ruling (Bluestein v. Skinner) demonstrates consistency in appellate-level treatment of random drug testing programs. Programs addressing a compelling government need to test safety-sensitive personnel should withstand constitutional challenges, provided that such programs ensure the integrity and reasonableness of collection, chain of custody, and analysis procedures. Public sector employers, however, must carefully consider the scope, method, and motive of any drug testing program before implementation. Case law suggests that, absent assurances of government need, procedural integrity, test accuracy, prosecutorial bans, and a nexus between employee duties and feared repercussions of a drug-related mishap, all drug testing programs may not be constitutional. The government's need to safeguard public health and welfare is discussed in the context of individual liberties and privacy considerations. 36 footnotes