The first section describes the extent and nature of adolescent substance use and abuse, based on current statistics. The second section discusses prevention and intervention strategies in terms of program-based primary and secondary efforts, including those that target high-risk youth, school-based and peer programs, and family intervention programs. Media and law enforcement approaches are the most popular types of community-wide prevention methods to drug prevention, but comprehensive community-based programs are showing some promise. Finally, the article discusses tertiary prevention, i.e., the treatment of adolescent substance abuse. 1 table, 1 note, and 76 references