The introduction emphasizes the continuing need for collaboration between prevention researchers and practitioners. another paper sets the stage for prevention interventions with an overview of bio-psycho-social risk factors. One group of papers is data-oriented. Findings from a school prevention program that targeted third-grade to sixth-grade students is followed by a report on the use of sensation-seeking as a targeting variable for prevention campaigns. Another paper from this group presents findings from a study of Hungarian adolescents regarding alcohol use and associated socialization characteristics of family caring, family sanctions against alcohol use, school adjustment, and peer alcohol associations. A report on the use of substance- abuse curricula in California traditional and continuation high schools examines the immediate impact of nine social influence- oriented activities on drug-related knowledge and beliefs for students; the relative effectiveness of two program delivery methods (active versus passive) was also examined. Two other papers in this group analyze the use of parent and child reports of child and parent alcohol use, parenting attitudes, and practices and describe the use of squashing theory as a prediction analytical approach for drug behavior used in Italy. The third group of papers is conceptual. One paper presents a cognitive model of adolescent thinking related to substance use, and another describes an approach for conceptualizing high-risk prevention research. A paper suggests that cultural experiences of the target audience for prevention interventions must be incorporated into the intervention. Three main paradigms to guide prevention research are discussed in a paper, and the final report presents recommendations for both practice and research, with a view toward enhancing knowledge development. For individual papers, see NCJ-157444-56. Chapter references and a subject index