Sample characteristics included 96 percent male, 91 percent white, and a mean age of 36 years. The mean methadone dose was 81 mg. On average, subjects reported using greater than 5 grams of cocaine per week. Binge cocaine administration did not appear to be the typical use pattern. During daily periods of cocaine use, however, repeated injections of large amounts of cocaine were taken. The patients no longer had a primary opiate addiction; instead, the amount of cocaine used and the time spent using cocaine impeded their ability to work productively and increased their risk of medical complications associated with intravenous cocaine use. Findings emphasize the importance of developing novel treatment strategies for dually addicted individuals. 23 references and 1 figure