For this analysis, trimethylsilyl derivatives were prepared by using BSTFA with 1 percent TMCS. Derivatizing the reactive hydroxyl group with a less polar trimethylsilyl group eliminates the tailing peaks commonly seen with compounds like morphine. One figure in this report shows the analysis of a selection of opiates on an Rtx-5 column. This report advises that sensitivity and specificity in confirming the presence of opiates in different samples can be enhanced by selectively choosing certain ions to monitor. Identification based on the presence of distinctive, high mass ions is preferred, especially when analyzing derivatized compounds. Trimethylsilyl derivatives will add 72 amu for every hydroxyl group derivatized. Effective protocols for opiate analysis include extensive sample preparation and optimized instrument parameters. Derivative formation and the use of deactivated glassware, sample vials, and inlet liners will ensure maximum recoveries and response. Optimized detector parameters using selected ions for detection will aid in the identification of various compounds. 3 figures