Cognitive-behavioral coping skills treatment (CBT) is a short-term, focused approach to helping cocaine-dependent individuals become abstinent from cocaine and other substances. The underlying assumption is that learning processes play an important role in the development and continuation of cocaine abuse and dependence. These same learning processes can be used to help individuals reduce their drug use. This manual outlines several important features of CBT that make it particularly promising as a treatment for cocaine abuse and dependence. Following an overview of CBT, basic principles are outlined. The structure and format of sessions are then discussed, along with integrating CBT and medication. Goals and interventions are presented for sessions that deal with an introduction to treatment and CBT, coping with craving, shoring up motivation and commitment to stop, refusal skills/assertiveness, seemingly irrelevant decisions, an all-purpose coping plan, problem-solving, case management, and HIV risk reduction. The final and terminating session is also discussed. Appendixes address therapist selection, training, and supervision, as well as clinical research that supports CBT. 65 references.