The article analyzes how likely police-induced false confessions are to lead to the wrongful arrest, prosecution, conviction, and incarceration of the innocent. It examines with field data whether confession evidence substantially biases a trier of fact even when the defendant's statement was elicited by coercive methods. The article explores this issue with cases in which the defendant's statement not only has been coerced but also is demonstrably unreliable, and in which other evidence proves or strongly supports the defendant's innocence. In addition, the article discusses the selection and classification of the 60 disputed confession cases under study; describes findings; analyzes the deprivations of liberty and miscarriages of justice associated with the cases described; and discusses the import of this research. Notes, tables