For the purposes of this chapter, the authors use the definition of "violence" developed by Roark (1995), who defines violence as "behavior by intent, action, and/or outcome which harms another person." The kinds of behavior included in this definition are murder; assault; robbery; vandalism; domestic violence; sexual harassment; dating violence; and harassment against minorities, gays, and lesbians. The authors' brief review of the relevant research concludes that there is a linkage between violence and the use of substances. Although many of these studies do not prove causality, the constant linkages between the use of controlled substances and violent acts, coupled with what is known about how these substances act on the human body suggests that there is a causal linkage. This chapter discusses how drugs affect the human body and contribute to violent behavior. Data from the mid-1990's indicate the substantial use of drugs and alcohol by college students. Overall, college and university administrations and students are mounting strong efforts to address drug and alcohol abuse. An effective campus-based effort to counter drug/alcohol abuse is a complex tapestry that integrates six distinct, yet overlapping dimensions: institution-wide, comprehensive, broad-based, clear outcomes, multitargeted, and cultural awakening. Campus implementation steps are outlined. 28 references