The EPRI guides State, local, and regional jurisdictions in performing an evaluation designed to determine the extent to which they are prepared to respond to a public health threat or emergency and to assess progress toward achieving critical and enhanced capacities and critical benchmarks. It also identifies gaps in preparedness and response capacities that will be the focus of future proposed work plans, as well as the State Local Public Health Infrastructure Improvement Plan. Further, the EPRI provides a framework for each State to characterize the status of its public health infrastructure. The EPRI contains six chapters that correspond directly with the six funded focus areas of the grant guidance: preparedness planning and readiness assessment, surveillance and epidemiology capacity, laboratory capacity-biologic agents, health alert network/communications and information technology, risk communications and health information dissemination, and education and training. A resource dictionary for the EPRI is included.