For this study, searches were conducted for double-blind, placebo-controlled studies of atypical antipsychotics for aggression. In addition a literature search was conducted on the use of other pharmacological agents and psychosocial interventions for aggression, for the period of 1990 to the present. Case reports and adult literature concerning the safety of atypical antipsychotics were used where controlled data for youth were lacking, as it was found that controlled data on the treatment of aggression in youth was scarce. Psychosocial interventions may be effective alone or in combination with pharmacological treatments, and psychotropic agents have been shown to have limited efficacy in reducing aggression. Antipsychotics, particularly the atypical antipsychotics, show substantial success in the treatment of aggression in selected pediatric populations. Atypical antipsychotics are generally associated with fewer extrapyramidal symptoms than are typical antipsychotics. In conclusion, it was found that psychosocial interventions and atypical antipsychotics are promising treatments for aggressive youth. It is recommended that double-blind studies be conducted to examine the safety and efficacy of atypical antipsychotics compared to each other and to medications from other classes, the efficacy of specific medications for different subtypes of aggression, combining various psychotropic medications, optimal dosages, and long-term safety. A list of source references is provided.