The National Institute on Drug Abuse (NIDA) supports a significantly large portion of the world’s research on drug abuse and addiction. Research funded by NIDA enables scientists to apply the most advanced techniques available on the study of every aspect of drug abuse. This report presents 32 selections of articles and the research findings specific to the topic area of nicotine that are reprinted from NIDA’s research newsletter dating from 1995 to 2001. In focusing on the area of nicotine, research findings are presented in the areas of nicotine use and brain development; the vulnerability of adolescents women, and Whites to becoming nicotine dependent; nicotine and pregnancy and prenatal exposure to nicotine; nicotine and anxiety disorders; treating nicotine dependence; nicotine vaccine; the relationship between nicotine and drug abuse and conduct disorder; nicotine craving and the increase in the use of cocaine and heroin; nicotine treatment guidelines; nicotine use and genetics; tobacco research centers; nicotine medication; therapies and teen nicotine use; nicotine and the brain’s pleasure circuit; nicotine and psychoactive ingredients; and nicotine use and increased risk of lung infections.