People who kill strangers all have their own macabre reasons for their acts. There is much to learn from those who are willing to divulge their reasons, and sometimes from the acts of those who don’t. Lieutenant Nelson Andreu retired from the Miami Police Department in 2002 where during his tenure as a detective, he investigated six serial murder cases. In this article he first attempts to track similarities among people who kill strangers and then presents how the six cases he investigated may or may not have conformed to these generalities. Five generalities are discussed based on a consensus of the majority of criminal profilers, based on actual cases investigated: (1) common knowledge, (2) genesis of a serial killer, (3) victim selection, (4) victim objectification, and (5) denouement. A summary of these generalities begins with that most, although not all, serial killers begin their lives as petty criminals. They frequently suffer from low self-esteem, often complicated by some type of sexual dysfunction. Many were victims of sexual abuse or raised in a violent household. Generally, serial killers select their victims based on certain physical and/or personal characteristics. When a serial killer begins their hunt for human prey, it is almost always true that they know absolutely nothing about the person who is to become their victim. Lastly, once a serial killer is in possession of a living victim and has the victim where he/she feels safe enough to act out his/her fantasies, the acts are often performed as if on “autopilot.” The killer’s acts appear to be a close reenactment of what they previously did in his/her imagination.