The general approach to new forms of crime based in the exploitation of new technologies and global economic structures requires the application of the scientific method to crime control. This involves the efficient and effective collection and analysis of data and evidence, to which logic is applied in the development of prevention, detection, investigation, and prosecution strategies and procedures. The response to new forms and methods of crime is currently plagued by low detection rates and failure to counter the sophisticated methods of transnational organized crime. This paper presents the case for emphasizing prevention that focuses on reducing or eliminating technological and economic vulnerabilities that have been exploited by criminals. Prevention strategies should include target hardening, access control, the screening of exits, the deflection of offenders, and the control of tools/weapons. The discussion of prevention is followed by a section on scientific developments that can aid in detecting new forms and methods of crime. Among the detection technologies discussed are electronic surveillance, computer analysis of fingerprints, and DNA analysis. The importance of training in these technologies and disciplines is emphasized. The paper concludes with a discussion of the implications of integrating a scientific approach into crime-control policy, with some examples provided. 2 figures, 2 tables, and 33 references