The criminal justice system of Ghana is in a fight against economic crime and money laundering. Ghana is in need of the cooperation and support of the international community to address these challenges. There is a need in the training of its officials of law enforcement agencies and authorities from financial and other institutions. In addition, the need exists for provision of financial and technical backup for the justice system and the police and states attorneys who handle criminal cases. This paper examines the economic crimes of fraud and money laundering in Ghana in an attempt to understand the drastic need for the development and implementation of countermeasures to deal with economic crimes. Institutions and measures examined in countering economic crime are police, the Serious Fraud Office, the Bank of Ghana, and the courts.