At the 6-month follow-up, those who had completed the curriculum had reduced their frequency of intercourse without a condom during the previous 3 months, the frequency of intercourse without a condom with steady partners, and the number of times they had intercourse in the previous 3 months. The curriculum also increased condom use at last intercourse. These behavioral effects, however, were no longer statistically significant at the 12-month and 18-month follow-ups. Overall, the curriculum's effects were modest and short-term. More research is needed to extend and sustain program effects, with attention to the role that interpersonal and institutional support play for alternative school students. The All4You! intervention featured 2 primary components that were integrated and delivered as a 14-session program (approximately 26 hours total). One component was a skills-based focus on ways to prevent HIV, other STDs, and pregnancy, and the other component consisted of service-learning activities. The focus of both components was on key risk and protective factors related to sexual behaviors. Lessons were drawn from two existing evidence-based curricula: Be Proud, Be Responsible and Safer Choices. The study involved a randomized controlled trial in 24 alternative schools located in 4 large urban counties in northern California. Thirteen schools were randomly assigned to receive the program intervention. The remaining 11 schools were used as control sites. A cohort of 988 students was assessed 4 times during an 18-month period, using a self-report questionnaire. 4 tables and 44 references