Estimates of past year drug use for persons aged 12 or older in 2004-2005 ranged from 5.9 percent in Iowa to 12.2 percent in Alaska. On the national level, drug use among adolescents aged 12 to 17 declined from 10.9 percent in 2003-2004 to 10.3 percent in 2004-2005. On the national level, in 2004-2005, 10.5 percent of all individuals aged 12 years and older reported past year marijuana use. Past month alcohol use among persons 12 or older in 2004-2005 ranged from a low of 30.1 percent in Utah to a high of 65.3 percent in Wisconsin. During 2004-2005, 41.2 percent of all persons aged 12 or older considered themselves at great risk for binge drinking. Nationally, past month tobacco use in 2004-2005 was 29.3 percent, with West Virginia having the highest rate at 40.9 percent for all persons aged 12 years or older. Past year rates of alcohol dependence remained stable between 2003-2004 and 2004-2005 at 7.6 percent and 7.7 percent respectively for all persons aged 12 years or older. Another 2.9 percent of persons aged 12 or older in 2004-2005 were dependent on illicit drugs during the past year. The national rate for needing but not receiving illicit drug treatment among persons aged 12 or older was 2.7 percent in 2004-2005, which is the same figure that was reported in 2003-2004. The report also reveals that in 2004-2005, West Virginia had the highest rate of serious psychological distress (SPD) (15.3 percent) during the past year for persons aged 18 or older while Hawaii had the lowest rate (9.8 percent). Finally, during 2004-2005, 7.7 percent of all persons aged 18 or older had a major depressive episode during the past year, with Utah reporting the highest rate (10.1 percent) and Hawaii reporting the lowest rate (6.7 percent). List of figures and tables, references, and appendix