The analysis indicates that the use of analytical methods for the characterization of anions found in explosives and poisons can be complementary aids to other forensic methods for establishing investigative leads. Specifically, the use of ion chromatography and capillary electrophoresis for the analytical separation of anions are particularly reliable. The analytical characterization of anions found in explosives and poisons is important because the substances are often water-soluble inorganic chemicals. Aqueous extractions of food or beverages to detect anions in poisons can be separated using ion chromatography or capillary electrophoresis. These two methods can also be used to identify the anion profile of inorganic bomb residues. The determination of poisons in foodstuff can also be analyzed by comparing the suspect foodstuff with reference substances. Additionally, separate ion analysis systems or instrumental techniques such as X-ray crystallography or elemental analysis can be used. Specific examples are provided throughout the article on anion analysis work conducted at the Forensic Science Research Unit of the FBI Laboratory in Quantico, Virginia.