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NCJRS Abstract

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NCJ Number: 219502 Find in a Library
Title: Investigation of a Unique Adjunct to Enzyme Immunoassay in Order to Rapidly Perform First-Pass Screening for Drugs and Poisons in Postmortem Toxicology Cases
Author(s): George Herrin Ph.D.; H. Horton McCurdy Ph.D.; William Wall B.S.; Lisa Holt M.S.
Corporate Author: Georgia Bureau of Investigation
United States of America
Date Published: 2006
Page Count: 42
Sponsoring Agency: Georgia Bureau of Investigation
Decatur, GA 30037
National Institute of Justice (NIJ)
Washington, DC 20531
NCJRS Photocopy Services
Rockville, MD 20849-6000
Grant Number: 2003-IJ-CX-K007
Sale Source: NCJRS Photocopy Services
Box 6000
Rockville, MD 20849-6000
United States of America
Document: PDF
Type: Report (Study/Research)
Format: Document
Language: English
Country: United States of America
Annotation: This report details a National Institute of Justice, grant funded project designed to investigate the potential use of novel methods and testing that facilitate the rapid identification and quantitation of various drugs as an alternative to conventional testing.
Abstract: It was demonstrated that a simple acetone extraction from blood was suitable for liquid chromatography/mass spectrometer/mass spectrometer (LC/MS/MS) analysis of a wide range of drugs encountered in forensic samples. During the project, methods were developed that facilitated rapid identification and quantitation of over 100 different drugs. There were some drugs (e.g. morphine, hydromorphone, and THCA) that did not produce adequate sensitivity or were not detected because of early elution from the column. It was also determined that some drugs had degraded during storage of blood samples. This type of information could prove important in cases where a significant time interval has elapsed between death or sample collection and the subsequent analysis.
Main Term(s): Blood/body fluid analysis
Index Term(s): Autopsy; Death investigations; Drug testing; Evidence identification; Forensic sciences; Poisons and poison analysis; Tissue analysis
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