Popular belief and old assumptions, as well as a failure to rethink the policy-level issue of reconfirming results, threaten to hold back progress in the field of forensic toxicology. Despite these challenges, the transition from a popular but limited technology to a new more sensitive technology is happening, offering significant advancements in the field of forensic toxicology. The implementation of LC/MS/MS is a major change occurring in many labs across the country. The suitability of LC/MS/MS as the basis for testing methods in toxicology laboratories may be eye-opening for many in the forensic field. It is a standardized analytical technique already heavily used in other fields, such as pharmaceutical drug discovery and development. LC/MS/MS can detect lower concentrations of drugs than existing or traditional systems. It is said that LC/MS/MS is on the way to developing into a new “Platinum Standard” for toxicology testing.