Data from the analysis indicate that time-space sampling was an effective strategy to screen club-going adults and to identify club drug users among them. The findings suggest that it might be possible to develop early drug prevention and educational interventions that could be specifically tailored to populations of a variety of race/ethnicity, gender, and sexual orientations. These findings have implications for future efforts using this methodology. Time-space sampling has been used to generate representative samples of both hard-to-reach and location-based populations. The random nature of time-space sampling methodology helps to address some of the issues around the generalizability of rates of club drug use among this population. However, because of its emphasis on multi-tiered randomization, some have questioned the feasibility of time-space sampling as a cost-effective strategy. In an effort to better understand issues related to drug use among club-going young adults ages 18 to 29 in New York City, two variations of time-space sampling methods were utilized and compared. Tables and references