Historically, prosecutors and legislators have responded to the increasing gang problem through intervention programs and suppression initiatives. Today, prosecutors have become more proactive and play an integral role in a variety of prevention and intervention efforts. With funding from the U.S. Department of Justice, Bureau of Justice Assistance, the National District Attorneys Association's American Prosecutors Research Institute initiated an effort to help prosecutors formulate a comprehensive response to gang problems in their communities. The Comprehensive Gang Response Model presented in this monograph is designed to help prosecutors and allied professionals design and implement gang initiatives that focus on specific needs of individual jurisdictions. The model consists of seven major components: assessment, mechanisms for action, organizational change, collaboration, community outreach, multidisciplinary interactive programming, and evaluation. Use of these major components discussed in this monograph will empower prosecutors to effectively respond to gang-related activities in their jurisdictions and produce safer communities.