The first of three sections presents an overview of methamphetamine and the effects of methamphetamine addiction. This section reports that the prolonged use of methamphetamine has severe psychological and physical effects on the user. In addition, individuals who produce methamphetamine and others who are exposed to methamphetamine lab sites or toxic waste products can suffer serious health consequences. Psychological effects of prolonged methamphetamine use include paranoia, depression, anxiety, delusions, hallucinations, and suicidal ideation. Physical effects include increased heart rate, high blood pressure, and irregular heartbeat. Adverse effects on the brain can produce delusions/hallucinations and reduced mental flexibility. Section II provides guidelines for assessment, treatment, and recovery. Assessment determines the severity of drug use and the status of client functioning in key areas of his/her life. This is done through assessment interviews and biological testing. Regarding treatment, a range of components should be used, particularly those that address cognitive deficits. Social support groups, such as those found in 12-step groups should be encouraged, along with medical and psychiatric care. Individualized treatment components should be tailored to abuse history, the severity of dependence, and mode of administration of the drug. Guidelines also address co-occurring disorder, detoxification, outpatient treatment, engaging clients in treatment, addressing related dental disease, coping with craving for the drug, and recovery and relapse. Section III focuses on the nature and treatment of methamphetamine among special populations (women, adolescents and young adults, Latinos, those with HIV/Hepatitis C, and gay men). Section references