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NCJ Number: NCJ 231590     Find in a Library
Title: Mass Spectral and Chromatographic Studies on a Series of Regioisomers and Isobaric Derivatives Related To Methylenedioxymethamphetamines
Author(s): Tamer A. Awad
Date Published: 08/2010
Page Count: 315
Sponsoring Agency: National Institute of Justice
US Department of Justice
Office of Justice Programs
United States of America
Grant Number: 2005-IJ-CX-K140
Sale Source: National Institute of Justice/NCJRS
Box 6000
Rockville, MD 20849
United States of America

NCJRS Photocopy Services
Box 6000
Rockville, MD 20849-6000
United States of America
Type: Research (Applied/Empirical)
Language: English
Country: United States of America
Annotation: This dissertation examines the potential for misidentification of 3,4-methylenedioxymethamphetamine (MDMA).
Abstract: The drug MDMA (3,4-methylenedioxymethamphetamine) has regioisomeric and isobaric substances of mass equivalence, which have similar analytical properties which can lead to misidentification. In this study, the direct and indirect regioisomers of MDMA and also isobaric substances related to MDMA were synthesized and compared to MDMA by using gas chromatographic and spectrometric techniques. Results of the analysis indicate that the direct regioisomers and isobaric substances of MDMA can not be easily differentiated by mass spectrometry or ultraviolet (UV) spectrophotometry. The synthesized compounds were converted to their perfluoroacyl derivatives in an effort to individualize their mass spectra and to improve chromatographic resolution. The study found that derivatized MDMA was easily distingushed from its derivatized direct and indirect regioisomers using mass spectrometry. In addition, unique fragment ions were observed for the various direct regioisomeric side chains and the methoxymethcathinones.
Main Term(s): Drug detection
Index Term(s): Testing and measurement ; Drug research ; Drug analysis ; Methamphetamine
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https://www.ncjrs.gov/App/Publications/abstract.aspx?ID=253652

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