The National Prevention Strategy is designed to move the Nation from a system of sick care to one based on wellness and prevention, building on the state-of-the-art clinical services available. This involves the development of partnerships among Federal, State, tribal, local, and territorial governments; business; industry; and other private-sector partners, philanthropic organizations, community and faith-based organizations, as well as private citizens committed to improving health through prevention. Strategic directions for this prevention effort is to build healthy and safe community environments, establish and improve clinical and community preventive services, empower people to engage in healthy activities and routines, and eliminate health disparities that exist in the U.S. population. Priorities that have been set for the prevention efforts are to encourage and facilitate tobacco-free living, prevent drug abuse and excessive alcohol use, promote healthy eating and active living, provide guidance for reducing injuries and violence, promote reproductive and sexual health, and facilitate mental and emotional well-being. Appendixes address the economic benefits of preventing disease; indicators for the National Prevention Strategy; stakeholder outreach and input; advisory group on prevention, health promotion, and integrative and public health; justification for evidence-based recommendations; references for the key documents; and notes.