The three "critically affected populations" that were the focus of the Summit were lesbian, gay, bisexual and transgender (LGBT) communities; justice-involved populations; and women. Within these populations, six domains were the focus of the Summit: criminal justice, HIV/AIDS and other sexually transmitted diseases, mental health services, prevention/public awareness, rural issues and treatment, and continuing care/recovery management and support services. Summit recommendations for policy and program pertain to data collection and research, cultural competency, access to substance abuse services, and best practices. The Summit agenda consisted of plenary sessions, "springboard" sessions, small group discussions, policy and program recommendations, and Action Team planning. The Summit was not intended to be a traditional conference on methamphetamine use. Rather, it was intended to convene key stakeholders from committed States for the purpose of developing a national agenda and create State/Territory-specific Action Plans with strategies for addressing systemic issues that focus on the impact of methamphetamine use on the most critically affected populations, using a public-health and public-safety perspective. Summit participants were aware that although methamphetamine was the convening topic, solutions would focus on systemic issues that involve the broader challenges of integrating public health and public safety responses to substance abuse. By the conclusion of the Summit, each Action Team had produced an Action Plan for addressing the health and safety of the critically affected populations in its State or Territory. The policy and program recommendations that emerged for each critically affected population will shape Federal policies and programs. 160 references, appended expanded summary of the Summit recommendations, State/Territorial Action Team Rosters, Steering committee membership, and participant list