The conference provided a forum for sharing information from a broad spectrum of disciplines, with the goal of formulating a definitive model for primary prevention of substance abuse among Black high-risk youth. The four plenary session presentations addressed the implications of alcohol and other drug use for Black America; the second cocaine epidemic; prevention models that target Black youth at high risk for substance abuse; primary prevention of substance abuse based a public health perspective applied in an urban environment; and an ecological model for the prevention of drug use. Summaries are provided of the 10 panel sessions. One addressed the incidence of substance abuse, and another focused on family, cultural, and environmental risk factors related to substance use among high-risk Black youth. Two other sessions considered the interaction of health and nutrition and international dimensions of drug trafficking. Another panel session discussed the pharmaceutical industry and whether it is "friend or foe" in the fight against substance abuse. Other sessions addressed systemic factors related to substance abuse; prevention models for high-risk Black youth that focus on the family and religion; the use of education and the media in prevention models for high-risk Black youth; the involvement of industry and government in substance-abuse prevention models for high-risk Black youth; and the involvement of health-care and civic organizations in prevention models for high-risk Black youth. Appended presentation of the forum background, the faculty list for the forum, and a fact sheet