Inhalant and prescription medication abuse, particularly among adolescents, are serious problems in our society. Several risk factors associated with inhalant and medication abuse among adolescents have been identified. As a result, adolescents may suffer multiple consequences in a range of developmental areas. The purpose of this article is to examine in-depth the prevalence, risk factors, and consequences associated with inhalant and prescription medication abuse among adolescents. Recommendations in the prevention and intervention of inhalant and prescription medication abuse are provided. (Published Abstract)