During Federal fiscal year 2010, 3.3 million referrals for child abuse and/or neglect were estimated. These cases involved the alleged maltreatment of approximately 5.9 million children. Of these referrals, 45 States reported counts of both screened-in and screened-out referrals. Based on these data, 60.7 percent were screened in, with a range of 25.2 to 98.7 percent among the States, and 39.3 percent were screened out, with a range of 1.3 to 74.8 percent among the States. Of the nearly 2 million reports that were screened in and received a CPS response, 90.3 percent received an investigation response, and 9.7 percent received an alternative response. Of the 1,793,724 reports that received an investigation, 436,321 were substantiated; 24,976 were found to be indicated; and 1,262,118 were found to be unsubstantiated. For 2010, just over half of the reports of alleged child abuse and neglect were made by professionals, which mean that the person had contact with the alleged victim as part of the reporter's job. This includes teachers, police officers, lawyers, and social services staff. "Other" and unknown report sources submitted 13.7 percent of the reports. All States and two U.S. Territories submitted data on the dispositions of cases that received one or more CPS responses. Just over 3.6 million children were subjects of at least one report and received one or more dispositions. 61 tables, 14 figures, appendixes, and 6 endnotes