skip navigation

PUBLICATIONS

Register for Latest Research

Stay Informed
Register with NCJRS to receive NCJRS's biweekly e-newsletter JUSTINFO and additional periodic emails from NCJRS and the NCJRS federal sponsors that highlight the latest research published or sponsored by the Office of Justice Programs.

NCJRS Abstract

The document referenced below is part of the NCJRS Virtual Library collection. To conduct further searches of the collection, visit the Virtual Library. See the Obtain Documents page for direction on how to access resources online, via mail, through interlibrary loans, or in a local library.

 

NCJ Number: 248545 Add to Shopping cart Find in a Library
Title: Analytical and Synthetic Studies on Designer Drugs of the Piperazine Class
Author(s): C. R. Clark; Jack DeRuiter
Corporate Author: Auburn University
United States of America
Date Published: July 2014
Page Count: 539
Sponsoring Agency: Auburn University
Auburn, AL 36849
Grant Number: 2011-DN-BX-K530
Document: PDF
Type: Report (Study/Research) ; Research Paper
Format: Document; Document (Online)
Language: English
Country: United States of America
Annotation: The purpose of this project was to develop specific analytical methods for the identification of piperazines, compounds that have appeared on the illicit drug market in recent years and may represent a new class of designer drugs.
Abstract: This project addressed issues of resolution and discriminatory capabilities in controlled substance analysis with the goal of providing additional reliability and selectivity for forensic evidence and analytical data of piperazines. A number of piperazine-containing compounds have appeared on the illicit drug market in recent years (benzyl-, phenyl-, benzoyl- and designer phenethyl- piperazines) and these compounds may represent a new class of designer drugs. Some of these piperazine compounds are commercially available and others are designer analogues that can be synthesized in clandestine labs. Restricting the availability of piperazine would require placing dozens of substances from commercial sources around the globe under Federal control and modern forensics must be able to identify the compounds, and its analogues, as a controlled substance. Overall, this project evaluated the potential forensic interests of organic synthesis piperazine and more than 100 substitutes. Chemical characterization analysis included common to forensic science lab tools, such as MS and IR. The project has completed the following: 1) Synthesis of aromatic ring substituted benzylpiperazines focusing on those aromatic ring substituents commonly found in ring substituted phenethylamines drugs of abuse and the most significant substituents of isobaric equivalence. 2) Synthesis of aromatic ring substituted phenylpiperazines following the same general protocol. 3) Synthesis of substituted benzoyl-piperazines focusing on aromatic ring substituents of designer interest. 4) Synthesis of selected phenethyl-piperazines. 5) GC-MS evaluation of the regioisomeric and isobaric piperazines. 6) Evaluation of GC methods for the separation of all isomers producing equivalent mass spectra. 7) Evaluation of chemical derivatives of these isomers for differential mass spectral properties. And, 8) Evaluation of GC-MS and IR data for specific differentiation of all isomers producing equivalent mass spectra. 28 Chapters with conclusions and references, Tables and Figures, Appendices.
Main Term(s): Designer drugs
Index Term(s): Controlled Substances; Drug analysis; Drug information; Drug manufacturing; Drug research; Drug sources; Drugs; Illegal Substances; National Institute of Justice (NIJ); NIJ final report; NIJ Resources
Note: This document is a research report submitted to the U.S. Department of Justice. This report has not been published by the Department. Opinions or points of view expressed are those of the author(s) and do not necessarily reflect the official position or policies of the U.S. Department of Justice.
To cite this abstract, use the following link:
http://www.ncjrs.gov/App/publications/abstract.aspx?ID=270648

*A link to the full-text document is provided whenever possible. For documents not available online, a link to the publisher's website is provided. Tell us how you use the NCJRS Library and Abstracts Database - send us your feedback.