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	NCJ Number:		NCJ 250512
	Title:		The Utility of Ultra High Performance Supercritical Fluid Chromatography for the Analysis of Seized Drugs: Application to Synthetic Cannabinoids and Bath Salts
	URL(s):		PDF
	Author(s):		Ira S. Lurie
	Corporate Author:		George Washington University United States of America
	Date Published:		08/2017
	Page Count:		103
	Annotation:		This project examined the role of ultra-high- performance supercritical fluid chromatography (UHPSFC) as a separation technique for forensic drug analysis, with attention to the separation of emerging drugs such as synthetic cannabinoids and bath salts.
	Abstract:		The use of emerging drugs that are synthesized to circumvent the controlled substances laws has greatly increased over the last few years. New structurally similar compounds, such as synthetic cannabinoids and bath salts, are created by slightly modifying the chemical structure of a controlled substance. For the analysis of these solutes for legal purposes, the desired analytical method should distinguish between similar solutes (analogues, homologues, positional isomers, and diastereoisomers). Separation methods such as liquid chromatography (HPLC, UHPLC) and gas chromatography (GC) have played a major role in the analysis of synthetic cannabinoids and bath salts. The current project has demonstrated that UHPSFC has the potential to be superior to UHPLC and/or GC for the analysis of similar solutes, such as positional isomers of synthetic cannabinoids and bath salts, as well as diastereoisomers of synthetic cannabinoids. For the separation of a diverse group for each class of emerging groups, including mainly non-isomeric solutes, UHPSFC has been demonstrated to be orthogonal to GC and UHPLC. This project thus concludes that the use of UHPSFC would assist the criminal justice system in the adjudication of emerging drug cases. It would be particularly useful in determining which, if any, controlled substances are present in seized drugs, particularly emerging drugs. In addition to these outcomes and recommendations, this report describes the project’s design, methods, and data analysis. 29 figures, 16 tables, and 7 references
	Main Term(s):		Drug analysis
	Index Term(s):		Chromatography ; National Institute of Justice (NIJ) ; Designer drugs ; NIJ final report
	Sponsoring Agency:		National Institute of Justice (NIJ) US Department of Justice Office of Justice Programs United States of America
	Grant Number:		2014-R2-CX-K009
	Sale Source:		US Dept of Justice NIJ Pub 810 Seventh Street, NW Washington, DC 20531 United States of America
	Type:		Program/Project Description ; Report (Study/Research) ; Research (Applied/Empirical) ; Report (Grant Sponsored)
	Country:		United States of America
	Language:		English
	To cite this abstract, use the following link: https://www.ncjrs.gov/App/Publications/abstract.aspx?ID=272677
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