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NCJRS Abstract

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1 record(s) found

 

NCJ Number: 254407 Find in a Library
Title: Evaluation of High Density SNP Microarrays to Obtain Phenotypic and Ancestry Information From Skeletal Remains
Document: PDF
Author(s): Giovanna M. Vidoli; Amy Mundorff; Jonathan Davoren
Date Published: December 2019
Annotation: This is the Final Summary Overview of the findings and methodology of a research project with the goal of characterizing the performance of a pre-configured panel of ancestry and phenotypically informative SNPs on DNA extracted from a controlled sample of well-documented skeletal cases; and the SNP results were compared with the individual’s self-reported data and the project’s anthropological analysis of ancestry.
Abstract: The study used human remains obtained through the Forensic Anthropology Center (FAC) Body Donation Program at the University of Tennessee, Knoxville. The research produced the following four findings: 1) the SNP chip testing results had a significant decline in accuracy when the call rates were below 70 percent; 2) DNA from blood samples yielded accurate phenotype and ancestry predictions at 10 Ng of input DNA, but bones required at least 250 Ng of DNA to have a call rate over 70 percent; 3) phenotypic information was determined for DNA from about 50 percent of the bone samples and 67 percent of the blood samples at a 6-year postmortem interval; and 4) anthropological assessments were mostly consistent with self-reported ancestry, but the non-metric assessments did not capture the phenotypic variation in human groups. This report advises that the greatest potential gain from this research is the demonstration of a new probative tool to assist in identifying human skeletal remains for the forensic and criminal justice community. Information is provided on the dissemination of project results. 2 tables
Main Term(s): Forensic sciences
Index Term(s): Ancestral DNA; Bone analysis; Death investigations; National Institute of Justice (NIJ); NIJ final report; Victim identification
Grant Number: 2014-DN-BX-K035
Sponsoring Agency: National Institute of Justice (NIJ)
Washington, DC 20531
University of Tennessee
Knoxville, TN 37996
US Dept of Justice NIJ Pub
Washington, DC 20531
Corporate Author: University of Tennessee
United States of America
Sale Source: US Dept of Justice NIJ Pub
810 Seventh Street, NW
Washington, DC 20531
United States of America
Page Count: 19
Format: Document; Document (Online)
Type: Program/Project Description; Report (Grant Sponsored); Report (Study/Research); Report (Summary); Research (Applied/Empirical)
Language: English
Country: United States of America
To cite this abstract, use the following link:
http://www.ncjrs.gov/App/publications/abstract.aspx?ID=277651

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