The forensic toxicologist should obtain a complete set of specimens at autopsy. Annual statistics, showing patterns of drug and chemical deaths in a particular area, are also a useful tool to toxicologists. Specimens should be collected in individual clean glass containers with Teflon-lined caps. Specimens should be identified and sent to the laboratory as soon as possible. The following specimen samples should be available in all cases: blood, all bile, total gastric contents, liver and one kidney, a protein of fat and muscle, and at least one half of the brain. Sampling of environmental materials may help solve certain cases. Forms with which toxicologists should be familiar are included. Tables and 6 references are supplied.