On the basis of cultural variations between the South and other parts of the country, the proportion of the population below the poverty line and the level of income inequality are hypothesized to have stronger positive effects on the homicide rate in nonsouthern than in southern cities. Regression results for a sample of 256 nonsouthern cities and a sample of 91 southern cities do not support the hypothesis for the measure of income inequality, however. The Gini coefficient of family income concentration has no significant effect in either region. In contrast, the results for the poverty measure are consistent with expectations. The proportion below the poverty line has a significant, positive effect on the homicide rate only in the nonsouthern sample. These findings suggest that the impact of economic deprivation on rates of violent crime is likely to vary appreciably depending on the general cultural context. (Publisher abstract)