The research focused on the additive and interactive associations of Perceived Parental Reciprocity, as measured using the Perception of Parental Reciprocity Scale (POPRS), and Perceived Parental Approval of juvenile drug use. The study participants were 433 urban high school students in two high schools in a city in Canada. The youths were categorized as abstainers, experimenters, and regular users of alcohol, tobacco, and marijuana. Results revealed that the frequency of use of any of the drugs was positively associated with Perceived Parental Approval and negatively associated with Perceived Parental Reciprocity. However, the association with POPRS depended on the type of drug and the stage of drug use. The hypothesis of an interactive association of the two parenting variables and the frequency of drug use was supported only for tobacco, but the direction of the interaction was the reverse of what was expected. Figure, tables, notes, and 64 references