Cocaine and heroin are the most significantly damaging illegal drugs of abuse; they start with plants grown outside the United States. Marijuana is grown both inside and outside the United States. Chemical precursors for methamphetamines and other countries also come largely from outside the country. In addition, the criminal business enterprises that traffic drugs live, manage their illegal enterprises, launder money, and invest and enjoy their profits in other countries. The National Drug Control Strategy defines five strategic goals as well as specific near-term and medium-term objectives to reduce illicit drug use and its consequences in the United States. Efforts focus on policy and diplomacy, support for operations outside the United States, narcotics control assistance to other governments, and interdiction programs. Further efforts and improved international cooperation will make great progress possible.